The massive growth of compound activity data provides opportunities and challenges for medicinal chemistry. Conventional approaches for the analysis of structure-­activity relationships (SARs) are not suitable for the exploration and exploitation of this unprecedented knowledge base. Recently, new computational methodologies have been introduced for large-scale SAR analysis that put emphasis on visualization to provide an intuitive access to complex...

Why are individuals different? Why do the same mutations in the genome have different effects on different individuals? Why does one twin get sick when another does not? How do sicknesses come about through the combination of different mutations? These are the questions which British scientist Dr Ben Lehner – ICREA Research Professor, EMBL-CRG ­Systems Biology Unit, at the Centre de Regulació Genòmica (CRG) in Barcelona – investigates in his...

The application of Fatty Acid-Binding Protein (FABP) as a plasma marker for the diagnosis of acute myo­cardial infarction was first suggested in 1988. Currently, FABP is proven to have added value for the diagnosis­ of patients presenting with chest pain suggestive of myocardial infarction, especially in the early hours after onset of symptoms. The routine application of FABP for this purpose not only will improve patient outcome but also markedly...